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In addition, senescence-associated secreted factors, such as interleukin 6 (IL-6), interleukin 8 (IL-8), also displayed similar expression profiles, particularly in Cys 2 -starved and erastin-treated cells (Fig

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It enters the cell via folate receptor (FR) or reduced folate carrier (RFC)

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Interestingly, the combination of PIO with DAPA showed the biggest reductions of hepatic tissue inhibitor of metalloproteinase 1 (TIMP-1) concentrations