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While same mitochondrial problems are present in the UMNs of ALS patients with TDP-43 pathology and UMNs of TDP-43 mouse models, and since pathologies are shared at a cellular level, regardless of species, we first analyzed the metabolite profile of both healthy and diseased motor cortex to investigate whether metabolomic changes occur with respect to TDP-43 pathology

This results in increased plasma GH levels, which would affect many biological processes

10.1093/braincomms/fcad213 Brain Commun

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Similar findings were identified in comparison with metformin (HR, 0.75