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Lowering GSH levels also triggers ferroptosis through deactivation of GPX4, leading to accumulation of lipid peroxides [87] In some cases, GSH depletion alone can induce therapeutic effects without relying on Fenton chemistry, which typically involves HO reacting with Fe 2 to form hydroxyl radicals (OH) that damage critical biomolecules such as DNA, proteins, and lipids
The IOMs safe upper limit for daily vitamin D intake is 4,000 IU
Some medications may require single-dose sterile water or other specific diluents
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TZD, thiazolidinedione
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