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The study, The Dermatologic Hazards of Nail Product Usage, outlined allergic contact dermatitis from nail product usage

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A 2026 Oxford University study found patients regained an average of 0.8 kg (about 1.7 lbs) per month after stopping

Using an ERE-luciferase mouse, a reporter mouse that allows monitoring of ER transcriptional activity in a spatiotemporal manner, it was demonstrated that estrogen signaling is locally activated in keratinocytes in vitro (with 1 nM E2) and in vivo (with 10 nM E2)