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No evidence of cardiac, hepatic, or renal toxicity, changes in serum lipids, or clinically relevant changes in laboratory parameters, vital signs, electrocardiograms, or abnormal findings upon physical examinations have been observed

GLP-1s are a relatively new class of prescription medications primarily used to manage type 2 diabetes by improving blood sugar levels

In obese and T2D/obese rat models, liraglutide administration significantly increased the Bacteroidetes/Firmicutes ratio as well as reduced the abundance of obesity-related phylotypes such as Romboutsia, Ruminiclostridium, and Erysipelotrichaceae while increasing lean-related phylotypes like Prevotella [190]

10.1016/j.phrs.2020.104784 162 WilliamsP

L-Arginine and L-Citrulline have documented interaction profiles with nitrate medications, antihypertensive drugs, and PDE5 inhibitors

J Transl Med 14:290