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GLP-1 medications improve insulin sensitivity in liver cells, reduce oxidative stress, and activate cellular cleaning processes like macroautophagy that help remove excess fat 19

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The pattern over time is more informative than any single meal

In addition, the mRNA expression of BMAL1 , PER2 , and CRY1 in visceral fat is closely related to the increase in waist circumference which is an indicator of metabolic syndrome ( The second is that the circadian clock system may control the rate-limiting steps of the metabolic process (Panda et al., 2002)

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Roux-en-Y versus one-anastomosis gastric bypass (RYSA study): weight loss, metabolic improvements, and nutrition at 1 year after surgery, a multicenter randomized controlled trial