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Among the GLP-1 drugs currently available, tirzepatide and semaglutide both stand out as the most effective for weight management

mTORC1 signals are mediated by several pathways like IGF1, IGF2, insulin through AMPK

PF-06882961 was a partial agonist in recruiting Arr2 (EC 50 = 490 nM, E max = 36%), while exenatide (Arr2 EC 50 = 9.0 nM, E max = 75%) and liraglutide (Arr2 EC 50 = 20 nM, E max = 99%) were respectively 54- and 23-fold more potent with greater E max values

It would be of great interest to determine whether it is possible to stimulate, also in a clinical setting, specific GLP-1 populations

Ask about stability data for the specific sublingual formulation