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Mulhern, M

Population pharmacokinetics of subcutaneous infliximab CT-P13 in Crohns disease and ulcerative colitis

Several studies, however, have described increased GSTP1 expression in drug-resistant cell lines following exposure to drugs which are not detoxified by glutathione conjugation (Wang et al, 1989), or which are not GSTP1 substrates (Tew, 1994)a direct role for GSTP1 in platinum chemosensitivity therefore remains to be unequivocally established

The most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and abdominal discomfort, affecting up to 40% of patients initially

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