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Bilirubin causes protein oxidation, lipid peroxidation, decreased cellular glutathione content, increased lactate dehydrogenase levels, and nitric oxide release (via neuronal nitric oxide synthase activation via N-methyl-d aspartate receptor activation)

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doi: 10.1186/s12967-024-05245-0 9 CocciaMNardoneLRizzelloF

Studies have shown that supplementation with L-arginine and L-citrulline can lead to modest reductions in blood pressure in people with hypertension

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Reducing it before glucose dysregulation appears could, in theory, break the sequence that leads from obesity to prediabetes to diabetes