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In addition to sorafenib, sunitinib and glycogen synthase 1 inhibitors can produce synthetic lethal effects in RCC cells (143)

The diagnosis of 5-oxoprolinase deficiency is established by: Low activity of 5-oxoprolinase in nucleated cells such as leukocytes or cultured skin fibroblasts (5-oxoprolinase is not present in erythrocytes)

Excretion is presumed to occur primarily through renal and hepatic routes, based on typical peptide pharmacokinetics

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Also talk with your clinician if you have liver or kidney disease