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Fibromyalgia is complex and can involve widespread pain, fatigue, sleep disruption, mood changes, and nervous system sensitivity

This cardiovascular receptor response may explain why an increase in heart rate or blood pressure is not seen in most cases when p -synephrine is used alone or in combination with caffeine in dietary supplements, in spite of the fact that caffeine alone may produce modest increases in these parameters under some conditions 50 , 51

An IPGTT was then performed after 4 h of dosing with compounds 1 , 14 and 22 (Fig

Free Radic Res 44(7):72133

434 Interestingly, a clinical study published in Nature Metabolism in 2023 investigated the restorative effects of liraglutide on impaired associative learning in individuals with obesity