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GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase

Epub 2003 Jun 9

This reversible regulation is not just a protective measure

Relevncia translacional Embora os estudos pr-clnicos sejam essenciais para a compreenso dos mecanismos de ao e dos potenciais efeitos teraputicos da Ipamrelina, a traduo destes resultados para pacientes humanos requer mais investigao clnica

Introduction The main regulatory systems of multicellular organisms, the nervous, endocrine, and immune systems, have the same mechanisms of peptide regulation at autocrine, endocrine, neurocrine, and paracrine levels

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