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Cardiovascular Outcomes# EXSCEL Trial (Exenatide)# The EXSCEL trial (Holman et al., NEJM 2017) enrolled 14,752 patients with T2D (73.1% with prior CV disease): Primary MACE: HR 0.91 (95% CI 0.83-1.00, p=0.06 for superiority) Non-inferiority achieved

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Metabolaid is a clinically studied polyphenol blend shown to support satiety and metabolic health, with clinical studies reporting reductions in body fat mass of up to 6.9%, alongside effects on appetite-regulating pathways including GLP-1, and additional support for cholesterol and blood pressure

J Neurochem 106:455463 Shughrue PJ, Lane MV, Merchenthaler I (1996) Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus