Avoid taking high-dose B6 supplements without consulting your doctor: While the daily upper limit is set at 100 mg pyridoxine, there have been reported cases of pyridoxine-induced neuropathy in people taking 25 to 50 mg per day for longer than six months
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Understanding how these drugs work, their potential benefits, risks, and safe usage is essential for effective pain relief without unwanted side effects
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Nature 466 , 10691075 (2010)