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Recent research has demonstrated that the pathophysiology of IBD is largely influenced by T cell-mediated immune responses in the intestinal mucosa, specifically the imbalance in the dynamic equilibrium between Th17 and Treg cells, which is crucial for the onset and progression of IBD (179)

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Furthermore, Asn240 is suggested to critically influence monophenolase activity by creating a negative redox potential within the active site

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43 Timing: the placement of bedtime and awakening time within the 24-hour day