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Chronic alcoholic patients between the ages of 21 and 65 years were investigated for predisposition to acetaminophen hepatotoxicity caused by increased activity of the cytochrome P450 system and decreased hepatic GSH concentrations

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The experimental drug also appeared to be safe and tolerable, with adverse events similar to other GLP-1 drugs (mostly gastrointestinal and mostly mild to moderate in severity)

Nature Genetics, Volume 10, Issue 1, May 1995, Pages 111-113 Marvin Boris, M.D