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The Phase 3 TRIUMPH-4 trial pushed these numbers even higher, with the 12 mg dose achieving 28.7% mean weight loss at 68 weeks

For people with diabetes, glucose readings and low-glucose symptoms should be included when relevant

In one study involving 9,142 NHANES participants, a 16% lower prevalence of migraine was seen in those with the highest, versus the lowest, vitamin D levels (Hao 2025)

New England Journal of Medicine , 382(13), 1244-1256

Although lacosamide was not included in the ESSETT trial, it was a trial of first -line maintenance antiseizure medications

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