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Increased production of beneficial microbial metabolites, such as short-chain fatty acids, and reduced levels of harmful endotoxins, such as lipopolysaccharides, are associated with improved metabolic and inflammatory profiles

This adaptation takes approximately 2 to 4 weeks, which is why the standard protocol allows 4 weeks at each level before escalating

Drinking on an empty stomach raises both intoxication and the risk of low blood sugar, which the medication can make harder to predict