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Dickinson, D

Regulatory Toxicology and Pharmacology (2020) 12

doi: 10.1016/j.pnpbp.2007.05.012

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3 These polar elements participate in hydrogen bonding and electrostatic interactions within the receptor binding pocket, while surrounding lipophilic regions promote favorable pharmacokinetics and sustained GLP-1 receptor engagement. Basically, the drug developers ensured that part of the molecule is attracted to water, which helps the body absorb the medicine through the gastrointestinal tract

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