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For instance, PPR significantly alters the pharmacokinetics of carbamazepine, increasing its maximum plasma concentration, half-life, and area under the curve by 68.7, 47.9, and 43.2%, respectivelyelevating risks of drug toxicity (85)

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doi:10.1007/s00441-019-03016-8 Chang CH, Tsai WC, Hsu YH, Pang JH

Arch Virol 122:107118