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Despite its therapeutic efficacy, tacrolimus has a narrow therapeutic window (520 ng/mL whole blood 1012 h post-dose) and frequently displays episodes of toxicity, such as nephrotoxicity, neurotoxicity, and glucose intolerance (Malaekeh-Nikouei and Davies, 2009)

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(PubMed) Leppala JM, Virtamo J, Fogelholm R, et al