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282,283 These cells accumulate in the synovial membrane and subchondral bone, releasing pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which promote the degradation of joint cartilage and the inflammatory response

However, the innovations of GLP-1s meant they could mimic the hormone GLP-1 and be resistant to the DPP4 enzyme, so they had a lasting impact on blood sugar levels and appetite

It is studied in controlled models only

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These innovations hold promise for inducing long-term tolerance, but their clinical application is limited by regional variability, insufficient standardization, and a lack of human trials