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The REWIND study found CV benefits of treatment with dulaglutide in participants where only 32% had underlying CVD and who had low baseline HbA1c levels, thereby classifying the study population as a low-risk population compared to the other GLP-1RA CVOTs
The activated Akt subsequently modulates many downstream effector proteins associated in cell survival, proliferation, metabolism, and glucose transport (Fletcher et al
Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (81930019, 82341076) to Jin-Kui Yang
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As summarized in Table S1, the level of evidence is still low, derived mainly from in vitro studies, animal models, and small patient cohorts, with only limited data from RCT available
Beyond regulating blood sugar, GLP-1 receptor agonists reduce systemic inflammation, improve insulin sensitivity and promote weight loss all factors that can dampen tumor-promoting pathways
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