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However, they can still impact the endocrine system, insulin sensitivity, and IGF-1 axis with prolonged or high-dose use

Kosiborod MN, Deanfield J, Pratley R, Borlaug BA, Butler J, Davies MJ, Emerson SS, Kahn SE, Kitzman DW, Lingvay I, et al

Patient suitability must be assessed by the treating professional

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The result is reduced appetite, longer satiety, and gradual, sustained weight loss