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The conjugation of DOPAL to lysine residues interferes with many cellular events and down-regulates cell viability, as evidenced by ubiquitin oligomerization, accumulation of ubiquitinated proteins and impairment of UPS functions upon DOPAL challenges [71]

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Adems, dependiendo de la HbA1C inicial del paciente y para limitar el riesgo de hipoglucemia, puede ser til reducir la dosis de insulina concomitante, p

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