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Wegovy HD 7.2 mg, the recently approved higher-dose version of semaglutide, shows a similar dose-dependent increase, with dysesthesia reported in roughly 22% of people at that dose compared to about 6% at the standard 2.4 mg dose

There is a potential upside here: Eli Lilly is testing a maintenance dose of 4 mg in some of its Phase 3 trials

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doi: 10.1136/jmg.35.1.42

STING packaging from the trans-Golgi into clathrin-coated vesicles is mediated by the cargo adaptor complex 1 (AP-1), which also controls the termination of STING-dependent immune activation by an as of yet unknown mechanism (166) ( Figure 4 )