Because we considered a disruption of a thickened epidermis an extreme state of eczema and the repair of these areas an essential process in healing, we initially quantitated the effects of 1 M solutions of the peptides when included in the topical application with LPS or administered by subcutaneous injection of 1 nmol/g
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While showing promise in inflammatory and cancer disease models, these approaches face clinical translation challenges including DAMP molecular heterogeneity, inefficient drug delivery systems, and the complexity of multi-target synergistic mechanisms
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b , Quantification of MitoSOX red fluorescence in animals as depicted in ( a )