To further complicate drug development and diagnosis those AD criteria behaviors denoting cognitive decline can also result from a number of other clinical conditions including vascular disease (44, 45), frontotemporal dementia, PD-induced dementia, HIV infection (46, 47), as well as cumulative oxidative damage and toxicities accompanying normal aging (48)
The complications below are different
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The second-ranked candidate from the TPP study, thioredoxin reductase 1 (TXNRD1), is structurally and functionally similar to another candidate, glutathione disulfide reductase (GSRranked 6 th )
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