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The American Diabetes Association and American Association of Clinical Endocrinologists acknowledge the current evidence base while emphasizing the need for continued post-marketing surveillance to detect rare or delayed adverse effects that may not emerge in clinical trials of limited duration
Most patients taking semaglutide begin to notice reduced appetite within the first week, with steady weight loss of 12 pounds per week often starting between weeks 2 and 4
Risk: High costs, limited evidence of sustained outcomes without structured programs
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Rotate injection sites each week to prevent skin irritation
Author contributions SA: Methodology, Writing original draft
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