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Activation of AMPK by upstream kinases phosphorylates target enzymes, such as acetyl-coA carboxylase (ACC), leading to inhibition of lipogenic pathways and activation of FA oxidation 22
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[DOI] [PubMed] [Google Scholar] 106.Waters D.D., Alderman E.L., Hsia J., Howard B.V., Cobb F.R., Rogers W.J., et al
An RCT in patients receiving cisplatin chemotherapy found that NAC (1,200 mg/day) significantly reduced nephrotoxicity and ototoxicity without reducing antitumor efficacy (Riga et al., Am J Clin Oncol, 2013) [77]
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