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Seizure Monitoring: Patients with a history of epilepsy should be monitored closely during the initiation of therapy

Rare But Important Considerations In one PD trial, a participant on a highdose regimen (600 mg/day) developed tachycardia (rapid heart rate) and was later diagnosed with cardiomyopathy

Common Cutaneous Reactions: Urticaria and Contact Dermatitis One of the more frequently reported side effects of Vitamin B12 injections is cutaneous reactions, which can range from mild urticaria to severe anaphylaxis

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Over expression of the glutathione S-transferase gene from Pyrus pyrifolia fruit improves tolerance to abiotic stress in transgenic tobacco plants