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Preventing it requires a plan to manage returning hunger and preserve muscle mass

Thus, while KD can be tolerated in the general population, its implementation in elderly patients requires careful monitoring and individualized adjustments to prevent potentially serious adverse outcomes

Beyond a 15% deficit, you dont lose much more fat, but you do lose noticeably more muscle and bone

Glutamatergic projections participate in virtually all circuits in the adult central nervous system, including intracortical connections, cortical-subcortical connections, and subcortical systems such as the basal ganglia, cerebellum, thalamus, and brainstem circuits (Shepherd, 2004)

Metformin also improves insulin sensitivity via increased peripheral glucose uptake and utilization

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