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In naturally aged mice and in doxorubicin-treated mice, FOXO4-DRI treatment significantly improved physical fitness, restored fur density, improved renal function, and improved liver function effects attributed to the selective elimination of accumulated senescent cells

Nasal spray delivery offers rapid absorption and may provide systemic effects, while subcutaneous administration follows more traditional peptide research protocols

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Decisions on applications submitted in late 2025 are being released applicants can contact their contracting officers for updates on the status of their previously submitted applications

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