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Zepbound may offer greater weight loss with its dual-action mechanism, while Ozempic effectively reduces appetite

semaglutide: tirzepatide drives more weight loss (~20% vs ~15%), but semaglutide has the longer track record and in 2026 there's now a third oral option

Delayed gastric emptying, which is why food choices matter on this medication

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Routine concerns suitable for scheduled GP appointments include persistent nausea affecting quality of life, injection site reactions, or questions about dose adjustments