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This sounds beneficial but introduces unpredictability: the same oral dose could produce significantly higher plasma levels than intended, and the effect varies depending on the potency and half-life of the inhibitor

doi:10.1002/14651858.CD004440.pub2 (2007)

In IBS-C patients, acute mental and acoustic stress slow intestinal motility and increase the colonic spike-burst activity with higher levels of the vital stress hormone corticotropin-releasing factor (CRF)

Namikawa M, Kakizaki S, Kaira K, Tojima H, Yamazaki Y, Horiguchi N, et al

A cross-platform toolkit for mass spectrometry and proteomics

L.ZhangT.XuM.YaoJ.FangC