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Finally, an imbalance in GSSG:GSH ratio induced ER stress and dependency on the ER-associated degradation pathway, driven by a shift in protein disulfide isomerases towards their oxidized forms

Its highest concentrations are found in the liver, the bodys central organ for detoxification, where it plays a vital part in neutralizing harmful free radicals, supporting phase I and phase II liver detoxification pathways, and helping to eliminate heavy metals and environmental toxins

We examined several E3 ubiquitin ligases of PPAR and found that only NEDD4 was upregulated in our model (Fig

Langmuir 23, 19811987

[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Villanueva I., Gladem S.K., Kessler J., Bryant S.J

In contrast, mTORC1 is a stress-sensitive kinase complex inhibiting the process 27