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Similarly, Nestor et al

Gut 65 , 702711 (2016)

511 In the treatment of UC in children, patients may be prone to corticosteroid dependence, and infliximab can significantly relieve this dependence

On the other hand, insulin therapy remains a cornerstone for managing both type 1 and type 2 diabetes when the bodys insulin production or utilization is insufficient

In some cases, switching to a different GLP-1 agent or adjusting the dosing schedule may provide better tolerability

Obviously we do have 20 years, as you said, although it was with lower doses with individuals with type 2 diabetes using that as a group to compare to we have not seen any development of concerns that have emerged