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Globally, regardless of target specificity, the few antibodies validated from combinatorial libraries show lower purities, higher polydispersities and lower melting temperatures, T m , than the subset of validated antibodies from paired libraries, hinting at potentially poorer overall developability profiles for antibodies with random, non-cognate chain pairings
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Importantly, animals were singly housed to eliminate the exchange and cross-contamination of intestinal microbiomes, a factor that potentially biases studies with group-housed animals by minimizing microbiome variations for co-housed animals within a cohort
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