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The age-related decline in neuromodulator levels, combined with the lack of significant learning and memory effects from PXN LOW in aged animals (though a trend was noted, P = 0.07), may explain the reduced cognitive benefits of both caffeine and paraxanthine in older individuals

As erythrocytes lack crucial apoptotic mitochondrial and nuclear machinery, and in order to distinguish this cell death mode of erythrocytes from apoptosis, it was named eryptosis [24]

In brief, formalin-fixed, paraffin-embedded xenograft tumour sections were deparaffinized and rehydrated through graded alcohols

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