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CJC 1295 with DAC (Drug Affinity Complex) adds a lysine-linked maleimide group that covalently binds circulating albumin, extending the half-life to approximately 6 to 8 days and creating a non-pulsatile, sustained GH elevation that is physiologically quite different from normal secretion patterns

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We propose this is because Gdh2 is still present and has a high affinity for the enzymatic deamination of glutamate into -ketoglutarate

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doi: 10.1016/j.bbagen.2012.11.016