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While these findings provide preliminary evidence of the potential benefit of semaglutide in CUD in real-world populations, further preclinical studies are warranted to understand the underlying mechanism and randomized clinical trials are needed to support its use clinically for CUD

The study found an inverse relation between the emptying time from the gastric pouch, and plasma GLP-1 and insulin concentration with the meal, indicating that quicker transit time led to increases in insulin and GLP-1 plasma concentration and subsequent post-prandial hypoglycemia (43)

This helps promote a calorie deficit and, therefore, weight loss

These data are also consistent with patients in which DPP4 inhibitors (DPP4is) decrease HGP and are associated with reductions in glucagon (26, 34)

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Never double your dose to compensate for a missed injection