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Side Effect Comparison Both agents share gastrointestinal side effects as their primary tolerability issue

Because retatrutide is dose-escalated gradually in trial protocols, participants who are unable to tolerate higher doses due to side effects may not achieve the same degree of weight loss as those who reach the target maintenance dose

The body produces it in small amounts in the gastric juices, and although it naturally is used in the stomach, it has healing properties that can be used nearly anywhere in the body

Semaglutide injections copy a natural gut hormone called GLP-1

Side effect management during dose escalation The most common side effects, nausea, vomiting, diarrhea, constipation, and decreased appetite, are manageable for most users

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