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Among these, we discovered that the phosphorylation status of common oncogenic KRAS mutants impacts the action of small molecules, including clinically approved inhibitors

BTB and CNC homology 1 (Bach1) is a transcription factor that inhibits Nrf2 and is increased in COPD

Following stroke, however, the kynurenine pathway tends to become dysregulated, leading to the accumulation of neurotoxic metabolites such as 3-hydroxykynurenine (3-HK) and quinolinic acid (189)