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Collectively, these data demonstrate that EC-associated FBXW7 mutations severely impair the ubiquitination and degradation of ETV6, resulting in ETV6 protein accumulation in EC cells and patient tumor tissues

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encoded by the ABCC3 gene), is expressed in the basolateral membrane of intestinal enterocytes and transports folic acid and 5-methyl-THF into the blood

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One further caveat on the bell-shaped curve: none of the above should be read as an argument that larger doses are therefore better

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