Beyond digestive effects, patients report fatigue, headache, and reduced appetite as early-phase side effects
MOTS-c was found to upregulate key genes in the TGF-/Smad pathway (such as TGF-1, TGF-2, and Smad7) and increase the expression of bone formation markers like alkaline phosphatase (ALP), osteocalcin, and Runx2 in bone cells
It is taken daily by mouth
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