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This may be due to GLP-1R-mediated upregulation of the sympathetic system, as has recently been demonstrated for central GLP-1R effects on innate immunity 15

Just how far these drugs have penetrated the marketplace was illustrated in a Kaiser Family Foundation (KFF) tracking poll released this month

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Among those who had heard of Ozempic, Wegovy and similar drugs in February 2024, 53% said they are good weight loss options for people with obesity or a weight-related health condition

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