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Appelberg et al., 2009a,b

The formulation is completely safe, plant-derived, and has no side effects

Following the incubation period, the absorbance at 550 nm (A 550 ) was measured using a microplate reader

Functional and phenotypic analyses confirm the induction of a pancreatic endocrine fate, including positive dithizone (DTZ) staining indicative of insulin production, as well as the upregulation of key pancreatic markers such as Nestin , PDX-1 , paired box gene 4 ( PAX4 ), neurogenin 3 ( NGN3 ), Isl-1, MAFA, insulin, and glucose transporter 2 ( GLUT2 )

Kojic acid (KA), a fungal metabolite, is the most widely used skin-whitening agent with possible side effects being dermatitis, sensitization and erythema 9,16

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