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That is an issue because a dehydrated athlete will have more concentrated urine relative to a well-hydrated athlete, and so the concentration of any substances (prohibited or not) appearing in their urine will be higher, thus increasing the probability of an anti-doping rule violation being pursued against them simply because of their hydration status

Setting realistic expectations prevents premature discontinuation

The Journal of Clinical Endocrinology and Metabolism, 59 (1), 127-132

200mg (ascorbic acid) Vitamin E

So nothing else really mattered as much as inflammation

Of the total increase in risk, about 10% of that excess risk was estimated to be due to TMAO-related metabolites