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Specific protein 1 (SP1)-mediated upregulation of PRDX6 expression also prevented iron overload by regulating iron metabolism, restoring SLC7A11 activity and GSH activity, and further promoting the increase in GPX4 expression to prevent ferroptosis-associated DN [238]

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It provides a strong, effective GH pulse without significantly moving the needle on the hormones that cause the most problematic side effects