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Immunofluorescence was performed to analyze the expression of IB, an NF-B inhibitory protein

Whether VKOR is sufficient for the two-step reduction of K epo to KH 2 , and whether the antidotal effect of vitamin K is due to the competition of vitamin K with warfarin for binding to VKOR, or even due to the existence of a warfarin-resistant VKR (antidotal enzyme) that bypasses dysfunctional VKOR, have all remained elusive